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Journal of Materials Science: Materials in Electronics
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Iranian Journal of Veterinary Clinical Sciences
Study of the effect of phenylbutazone on various pharmacokinetic parameters of sodium thiopental in male dogs


 submission: - | acception: 16/11/2019 | publication: 04/07/2020

DOI 

Authors
mansour khorshidimotlagh1*, hamid rajaian2, mahdieh raeeszadeh3

1-،khorshidi@yahoo.com

2-،rajaian@yahoo.com

3-،vet_mr@yahoo.com



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Abstract

Drug interactions may affect on pharmacokinetic parameters of anesthetic agents. The purpose of this research was to investigate the effect of phenylbutazone on various pharmacokinetic parameters of Sodium thiopental in male dogs. Twelve male dogs were randomly divided into two (control and experimental) groups. Animal health was confirmed by clinical examination prior to testing. Equivalent doses of thiopental sodium (17 mg/kg) were intravenously administered following the injection of 0.9% normal saline (0.1 ml/kg) in control group and phenylbutazone 20% (20 mg/kg) via the same route in experimental group. After anesthesia, blood samples were collected at various time intervals and their sera were separated by centrifugation and were assayed for thiopental concentration using HPLC method. Elimination rate constant (kel), half-life (t1/2), volume of distribution (Vd) and clearance (Cl) of thiopental were determined non-compartmental analysis of the concentration-time curves. Results show a significant difference in thiopental pharmacokinetic parameters. The elimination rate constant and clearance in the experimental group were found to be less than those in the control group, but the half-life and Vd of thiopental were more than in the experimental group compared to those in the control group. This is probably as a result of displacement from binding sites by phenylbutazone which can lead to changes in pharmacokinetic parameters and duration action of thiopental .




Keywords

Pharmacokinetics drug interaction Thiopental male dog Phenylbutazone  



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